2010 GROVE CITY COLLEGE FOOTBALL SCHEDULE
| Date | Opponent | Location | Time | Result | Score |
| Sept. 4 | Carnegie Mellon | Grove City, Pa. | 1:30 PM | L | 28-21 |
| Sept. 11 | Lebanon Valley | Annville, Pa. | 1:00 PM | W | 17-14 |
| Sept. 18 | Westminster* | New Wilmington, Pa. | 1:00 PM | W | 31-16 |
| Sept. 25 | Waynesburg* | Waynesburg, Pa. | 1:30 PM | L | 42-16 |
| Oct. 9 | Thomas More* (Homecoming) | Grove City, Pa. | 2:00 PM | L | 31-9 |
| Oct. 16 | Geneva | Grove City, Pa. | 7:00 PM | W | 13-7 |
| Oct. 23 | Saint Vincent* | Latrobe, Pa. | 1:00 PM | L | 42-17 |
| Oct. 30 | Washington & Jefferson* | Washington, Pa. | 2:00 PM | L | 21-14 |
| Nov. 6 | Bethany* | Grove City, Pa. | 1:30 PM | W | 21-7 |
| Nov. 13 | Thiel* (27th Mercer County Cup) | Grove City, Pa. | 1:00 PM | W | 35-21 |
*-Presidents' Athletic Conference games
(Start Times Subject to Change)