| Career Strikeouts | |||
| Rank | Name | Seasons | K |
| 1 | Paul Barnes | 1974-77 | 164 |
| 2 | Erik Arnesen | 2003-06 | 146 |
| 3 | Ryan Carr | 2003-06 | 141 |
| 4 | Larry Sawyer | 1967-70 | 139 |
| 5 | Cory Metcalf | 2008-11 | 116 |
| 6 | Zach Hillegas | 2006-09 | 112 |
| 7 | Mike Herringshaw | 2007-10 | 111 |
| 8 | JG Louden | 1998-2001 | 108 |
| 9 | Chris Bowser | 2005-08 | 91 |
| 10 | Dave Meadows | 1988-91 | 90 |
| Single-Season Strikeouts | |||
| Rank | Name | Season | K |
| 1 | Erik Arnesen | 2006 | 84 |
| T2 | Paul Barnes | 1977 | 58 |
| Kyle Silk | 2011 | 58 | |
| 4 | Paul Barnes | 1976 | 56 |
| 5 | Nate Caldwell | 1992 | 51 |
| 6 | Bob Fishback | 1977 | 49 |
| 7 | Ray Savorn | 1962 | 44 |
| T8 | Bob Schleiden | 1974 | 43 |
| Cory Metcalf | 2011 | 43 | |
| John Bini | 2016 | 43 | |